In contrast to their role in cell types with higher energy demands, mitochondria in endothelial
cells primarily function in signaling cellular responses to environmental cues. This article …

Abstract α-Lipoic acid (LA; 5-(1, 2-dithiolan-3-yl) pentanoic acid) was originally isolated from
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …

Alpha-lipoic acid is a naturally occurring substance, essential for the function of different
enzymes that take part in mitochondria's oxidative metabolism. It is believed that alpha-lipoic …

Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative
stress that contributes to the pathogenesis of this debilitating disease. This has prompted …

Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties
which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely …

Diabetes is a chronic metabolic disorder that continues to present as a major health problem
worldwide. It is characterized by absolute or relative deficiencies in insulin secretion and/or …

We provide a comprehensive update on mitochondrial medicine therapies based on current
evidence and our single-center clinical experience to support or refute their use, and provide …

Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in late December
2019. Since then, COVID-19 has spread rapidly worldwide and was declared a global …

Objective This systematic review and meta-analysis of randomized controlled trials (RCTs)
was performed to summarize the effect of alpha-lipoic acid (ALA) supplementation on …

Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates
this process is poorly understood. Here, we identify mitochondrial lipoylation as a previously …