The promise for histone methyltransferase inhibitors for epigenetic therapy in clinical oncology: a narrative review
Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …
specific gene expression in mammals. Changes in gene expression and malignant cellular …
Protein arginine methyltransferase 5 (PRMT5) as an anticancer target and its inhibitor discovery
Y Wang, W Hu, Y Yuan - Journal of medicinal chemistry, 2018 - ACS Publications
PRMT5 is a major enzyme responsible for symmetric dimethylation of arginine residues on
both histone and non-histone proteins, regulating many biological pathways in mammalian …
both histone and non-histone proteins, regulating many biological pathways in mammalian …
Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body …
N Blagitko-Dorfs, P Schlosser, G Greve, D Pfeifer… - Leukemia, 2019 - nature.com
DNA methyltransferase inhibitors (DNMTi) approved for older AML patients are clinically
tested in combination with histone deacetylase inhibitors (HDACi). The mechanism of action …
tested in combination with histone deacetylase inhibitors (HDACi). The mechanism of action …