Background Every day the skin is constantly exposed to several harmful factors that induce
oxidative stress. When the cells are incapable to maintain the balance between antioxidant …

Our skin is the interface between us and our environment–a flexible barrier that has evolved
for protection, immunity, regulation and sensation. Once regarded as inert, we now know …

The outermost epidermal layer of the skin, the stratum corneum, is not simply a barrier that
safeguards skin integrity from external insults and invaders, it is also a delicately integrated …

Our skin contributes critically to health via its role as a barrier tissue, carefully regulating
passage of key substrates while also providing defense against exogenous threats …

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general
population. Skin barrier dysfunction is the central abnormality leading to AD. The cause of …

The human tear film is at the interface between the ocular surface and the external
environment. Although investigation has been hindered by its small volume, improvements …

New mass spectrometry imaging (MSI) techniques are gaining importance in various stages
of the drug discovery and development chain as well as in more fundamental studies of drug …

Characterization of the molecular structure of skin, especially the barrier layer, the stratum
corneum, is a key research priority for generating understanding to improve diagnostics, aid …

Dysregulated cholesterol metabolism is implicated in a number of neurological disorders.
Many sterols, including cholesterol and its precursors and metabolites, are biologically …

MS imaging (MSI) is a powerful tool in drug discovery because of its ability to interrogate a
wide range of endogenous and exogenous molecules in a broad variety of samples. The …