Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Quantitative susceptibility mapping (QSM) has enabled magnetic resonance imaging (MRI)
of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense …

Background: Magnetic resonance imaging (MRI) markers for chronic active lesions in MS
include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs). Objectives …

Quantitative susceptibility mapping (QSM) is an MR technique that depicts and quantifies
magnetic susceptibility sources. Mapping iron, the dominant susceptibility source in the …

New clinical activity in multiple sclerosis (MS) is often accompanied by acute inflammation
which subsides. However, there is growing evidence that a substantial proportion of lesions …

Background Use of χ-separation imaging can provide surrogates for iron and myelin that
relate closely to abnormal changes in multiple sclerosis (MS) lesions. Purpose To evaluate …

Abstract Quantitative Susceptibility Mapping (QSM), best known as a surrogate for tissue
iron content, is becoming a highly relevant MRI contrast for monitoring cellular and vascular …

Measuring iron content has practical clinical indications in the study of diseases such as
Parkinson's disease, Huntington's disease, ferritinopathies and multiple sclerosis as well as …

Magnetic resonance imaging (MRI) has developed into the most important tool for the
diagnosis and monitoring of multiple sclerosis (MS). Its high sensitivity for the evaluation of …

Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local
concentration of iron and myelin. Here, we describe a robust image processing pipeline for …