AS Carlessi, LA Borba, AI Zugno… - European Journal of …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a psychiatric condition that affects a large number of people in the world, and the treatment existents do not work for all individuals affected. Thus …
MP Dandekar, MSK Palepu, S Satti… - ACS Chemical …, 2022 - ACS Publications
Depression is a debilitating mental disorder that affects> 322 million people worldwide. Despite the availability of several antidepressant agents, many patients remain treatment …
Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied prognosis, chronic course, and duration of illness with reduced quality of life. One factor that …
Y Han, L Zhang, Q Wang, D Zhang, Q Zhao… - …, 2019 - Elsevier
Exposure to early adversity increases vulnerability to psychiatric disorders in later life. Microglia-mediated inflammation has been linked to psychopathology, so such inflammation …
C Catale, S Gironda, L Lo Iacono, V Carola - Journal of clinical medicine, 2020 - mdpi.com
The putative effects of early-life stress (ELS) on later behavior and neurobiology have been widely investigated. Recently, microglia have been implicated in mediating some of the …
BR Kouba, L de Araujo Borba, P Borges de Souza… - Cells, 2024 - mdpi.com
The involvement of central and peripheral inflammation in the pathogenesis and prognosis of major depressive disorder (MDD) has been demonstrated. The increase of pro …
The dynamic expansions and contractions of the microglia population in the central nervous system (CNS) to achieve homeostasis are likely vital for their function. Microglia respond to …
GZ Réus, AS Carlessi, RH Silva… - Oxidative medicine …, 2019 - Wiley Online Library
Both conditions, major depressive disorder (MDD) and diabetes mellitus (DM) are chronic and disabling diseases that affect a very significant percentage of the world's population …
G Warhaftig, D Almeida, G Turecki - Neuroscience & Biobehavioral …, 2023 - Elsevier
Early life adversity (ELA)-which includes physical, psychological, emotional, and sexual abuse is one of the most common predictors to diverse psychopathologies later in …