The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation

AL Comer, M Carrier, MÈ Tremblay… - Frontiers in cellular …, 2020 - frontiersin.org
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Gut microbiota–brain axis in depression: The role of neuroinflammation

AS Carlessi, LA Borba, AI Zugno… - European Journal of …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a psychiatric condition that affects a large number of
people in the world, and the treatment existents do not work for all individuals affected. Thus …

Multi-strain probiotic formulation reverses maternal separation and chronic unpredictable mild stress-generated anxiety-and depression-like phenotypes by …

MP Dandekar, MSK Palepu, S Satti… - ACS Chemical …, 2022 - ACS Publications
Depression is a debilitating mental disorder that affects> 322 million people worldwide.
Despite the availability of several antidepressant agents, many patients remain treatment …

Physical exercise and neuroinflammation in major depressive disorder

ZM Ignácio, RS da Silva, ME Plissari, J Quevedo… - Molecular …, 2019 - Springer
Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied
prognosis, chronic course, and duration of illness with reduced quality of life. One factor that …

Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation

Y Han, L Zhang, Q Wang, D Zhang, Q Zhao… - …, 2019 - Elsevier
Exposure to early adversity increases vulnerability to psychiatric disorders in later life.
Microglia-mediated inflammation has been linked to psychopathology, so such inflammation …

Microglial function in the effects of early-life stress on brain and behavioral development

C Catale, S Gironda, L Lo Iacono, V Carola - Journal of clinical medicine, 2020 - mdpi.com
The putative effects of early-life stress (ELS) on later behavior and neurobiology have been
widely investigated. Recently, microglia have been implicated in mediating some of the …

Role of inflammatory mechanisms in major depressive disorder: from etiology to potential pharmacological targets

BR Kouba, L de Araujo Borba, P Borges de Souza… - Cells, 2024 - mdpi.com
The involvement of central and peripheral inflammation in the pathogenesis and prognosis
of major depressive disorder (MDD) has been demonstrated. The increase of pro …

Regulation of microglia population dynamics throughout development, health, and disease

BP Hammond, R Manek, BJ Kerr, MS Macauley… - Glia, 2021 - Wiley Online Library
The dynamic expansions and contractions of the microglia population in the central nervous
system (CNS) to achieve homeostasis are likely vital for their function. Microglia respond to …

Relationship of oxidative stress as a link between diabetes mellitus and major depressive disorder

GZ Réus, AS Carlessi, RH Silva… - Oxidative medicine …, 2019 - Wiley Online Library
Both conditions, major depressive disorder (MDD) and diabetes mellitus (DM) are chronic
and disabling diseases that affect a very significant percentage of the world's population …

Early life adversity across different cell-types in the brain

G Warhaftig, D Almeida, G Turecki - Neuroscience & Biobehavioral …, 2023 - Elsevier
Early life adversity (ELA)-which includes physical, psychological, emotional, and sexual
abuse is one of the most common predictors to diverse psychopathologies later in …