Despite the recent technical developments, surgery on the thoracic aorta remains
challenging and is associated with significant mortality and morbidity. Decisions about when …

Atherosclerosis, the primary cause of cardiovascular diseases (CVDs), is characterized by
phenotypic changes in fibrous proliferation, chronic inflammation and lipid accumulation …

Structural vascular changes in two-kidney, one-clip (2K-1C) hypertension may result from
increased matrix metalloproteinase (MMP)-2 activity. MMP-2 activation is regulated by other …

Objective: Pathological aortic flow patterns differ significantly from haemodynamics within
the healthy aorta. Development and impact of pathological flow is largely unknown and …

Nebivolol and metoprolol are β 1-adrenergic receptor blockers with different properties. We
hypothesized that nebivolol, but not metoprolol, could attenuate prooxidant and profibrotic …

Increased aortic stiffness is an early and independent biomarker of cardiovascular disease.
Here we tested the hypothesis that vascular smooth muscle cells (VSMCs) contribute …

Thoracic aortic aneurysm and dissection (TAAD) is a deadly disease characterized by
intimal disruption induced by hemodynamic forces of the circulation. The effect of exercise in …

The objective of the present study is to investigate the effects of vanillic acid on blood
pressure, cardiac marker enzymes, left ventricular function and endothelial nitric oxide …

The purpose of this study was to investigate the difference of coronary artery disease (CAD)
severity and extent as well as plaque characteristics between patients with either one of …

Upregulation of inducible nitric oxide synthase (iNOS) has been reported in both
experimental and clinical hypertension. However, although pro‐inflammatory cytokines that …