Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Effective intracellular delivery of therapeutic proteins can potentially treat a wide array of
diseases. However, efficient delivery of functional proteins across the cell membrane …

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic
membrane coupling regions formed by the coupling of the mitochondrial outer membrane …

Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …

Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative
disorder characterized by progressive cognitive dysfunction. Epidemiological investigation …

Protein misfolding is prominent in early cellular pathology of Alzheimer's disease (AD),
implicating pathophysiological significance of endoplasmic reticulum stress/unfolded protein …

Telomeres, also known as the “protective caps” of our chromosomes, shorten with each cell
cycle due to the end replication problem. This process, termed telomere attrition, is …

Alzheimer's disease (AD) is the most common neurodegenerative disease. There are many
studies targeting extracellular deposits of amyloid β-peptide (Aβ) and intracellular …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease featured
with memory loss and cognitive function impairments. Chronic mitochondrial stress is a vital …