Lipid lowering with PCSK9 inhibitors
RT Dadu, CM Ballantyne - Nature Reviews Cardiology, 2014 - nature.com
Statins are the most-effective therapy currently available for lowering the LDL-cholesterol
(LDL-C) level and preventing cardiovascular events. Additional therapies are necessary for …
(LDL-C) level and preventing cardiovascular events. Additional therapies are necessary for …
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
Large-scale whole-genome sequencing studies have enabled the analysis of rare variants
(RVs) associated with complex phenotypes. Commonly used RV association tests have …
(RVs) associated with complex phenotypes. Commonly used RV association tests have …
[HTML][HTML] National Lipid Association recommendations for patient-centered management of dyslipidemia: part 2
TA Jacobson, KC Maki, CE Orringer, PH Jones… - Journal of clinical …, 2015 - Elsevier
Abstract An Expert Panel convened by the National Lipid Association previously developed
a consensus set of recommendations for the patient-centered management of dyslipidemia …
a consensus set of recommendations for the patient-centered management of dyslipidemia …
PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future
YJ Shimada, CP Cannon - European heart journal, 2015 - academic.oup.com
Reduction in low-density lipoprotein cholesterol (LDL-C), mainly with statins, has decreased
the risk of cardiovascular events over the last few decades. However, there are several …
the risk of cardiovascular events over the last few decades. However, there are several …
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations
Blood lipid concentrations are heritable risk factors associated with atherosclerosis and
cardiovascular diseases. Lipid traits exhibit considerable variation among populations of …
cardiovascular diseases. Lipid traits exhibit considerable variation among populations of …
PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites
ST Kent, RS Rosenson, CL Avery… - Circulation …, 2017 - Am Heart Assoc
Background—PCSK9 loss-of-function (LOF) variants allow for the examination of the effects
of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We …
of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We …
Living the PCSK9 Adventure: from the Identification of a New Gene in Familial Hypercholesterolemia Towards a Potential New Class of Anticholesterol Drugs
M Abifadel, S Elbitar, P El Khoury, Y Ghaleb… - Current atherosclerosis …, 2014 - Springer
A decade after our discovery of the involvement of proprotein convertase subtilisin/kexin
type 9 (PCSK9) in cholesterol metabolism through the identification of the first mutations …
type 9 (PCSK9) in cholesterol metabolism through the identification of the first mutations …
[HTML][HTML] An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes
L Zhang, T McCabe, JH Condra, YG Ni… - … journal of biological …, 2012 - ncbi.nlm.nih.gov
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for
treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with …
treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with …
Association of proprotein convertase subtilisin/kexin type 9 (PCSK9) with cardiovascular risk in primary prevention
YM Zhu, TJ Anderson, K Sikdar, M Fung… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in
the modulation of low-density lipoprotein metabolism. This study was conducted to evaluate …
the modulation of low-density lipoprotein metabolism. This study was conducted to evaluate …