Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Endothelial cells lining blood vessels regulate vascular barrier function, which controls the
passage of plasma proteins and circulating cells across the endothelium. In most normal …

Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary
hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability …

Vascular permeability is a vital function of the circulatory system that is regulated in large
part by the limited flux of solutes, water, and cells through the endothelial cell layer. One …

Endothelial cells form a semipermeable, regulated barrier that limits the passage of fluid,
small molecules, and leukocytes between the bloodstream and the surrounding tissues. The …

Elucidating the mechanisms underlying sprouting angiogenesis and permeability should
enable the development of more effective therapies for various diseases, including …

The endothelial cells (EC) of established blood vessels in adults remain extraordinarily
quiescent in the sense that they are not actively proliferating, but they fulfill the necessary …

C-terminal Src kinase (Csk) targets Src family kinases (SFKs) and thereby inactivates them.
We have previously shown that Csk binds to phosphorylated tyrosine 685 of VE-cadherin …

Activation of Src Family Kinase (SFK) signaling is required for the increase in endothelial
permeability induced by a variety of cytokines and growth factors. However, we previously …

Inflammation is an important pathogenic driving force in the genesis and development of
epilepsy. The latest researches demonstrated that IL-17A mediated blood–brain barrier …