Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

INTRODUCTION One fundamental property of the immune system is its ability to develop
memory of previous encounters, resulting in enhanced responsiveness to subsequent …

Generation of functionally mature organs requires exquisite control of transcriptional
programs governing cell state transitions during development. Despite advances in …

There is increasing evidence that both mechanical and biochemical signals play important
roles in development and disease. The development of complex organisms, in particular …

Human gut development requires the orchestrated interaction of differentiating cell types.
Here, we generate an in-depth single-cell map of the developing human intestine at 6–10 …

Intestinal organoids are fundamental in vitro tools that have enabled new research
opportunities in intestinal stem cell research. Organoids can also be transplanted in vivo …

Tissue stem cells are generated from a population of embryonic progenitors through organ-
specific morphogenetic events,. Although tissue stem cells are central to organ homeostasis …

The intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair.
A key part of the regenerative response is the transient reprogramming of epithelial cells into …

In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …