Allenes are the simplest class of cumulenes, with two contiguous C C bonds, and show
unique physical and chemical properties. These features make allenes particularly attractive …

The pool of abundant chiral terpene building blocks (ie,“chiral pool terpenes”) has long
served as a starting point for the chemical synthesis of complex natural products, including …

Allenes are a class of unique compounds with two π-orbitals perpendicular to each other.
The first synthesis can be traced back to 1887. 1 They also exist in many natural products …

First-row transition-metal-mediated reactions constitute an important and growing area of
research due to the low cost, low toxicity, and exceptional synthetic versatility of these …

Ingenol is a diterpenoid with unique architecture and has derivatives possessing important
anticancer activity, including the recently Food and Drug Administration–approved Picato, a …

Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …

There are still some synthetic chemists who hesitate to use metal-mediated or-catalysed
reactions. The Pauson–Khand reaction (PKR) is a powerful transformation that has now …

The first type II intramolecular [3+ 2] annulation of allenylsilane-ene has been achieved,
enabling diastereoselective and efficient construction of synthetically challenging bridged …

As a consequence of growing environmental awareness, it is now inappropriate to design a
synthetic metal‐mediated transformation that involves a noncatalytic use of toxic and …

Abstract The Pauson–Khand‐type reaction is formally a [2+ 2+ 1] cycloaddition involving an
alkyne, an alkene and carbon monoxide catalyzed or mediated by transition metal …