Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations

L Dresser, R Wlodarski, K Rezania… - Journal of clinical medicine, 2021 - mdpi.com
Myasthenia gravis (MG) is an autoimmune neurological disorder characterized by defective
transmission at the neuromuscular junction. The incidence of the disease is 4.1 to 30 cases …

Autoantibody specificities in myasthenia gravis; implications for improved diagnostics and therapeutics

K Lazaridis, SJ Tzartos - Frontiers in immunology, 2020 - frontiersin.org
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and
fatiguability of skeletal muscles. It is an antibody-mediated disease, caused by …

Neuromuscular junction dysfunction in amyotrophic lateral sclerosis

S Verma, S Khurana, A Vats, B Sahu, NK Ganguly… - Molecular …, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …

Myasthenia gravis: pathogenic effects of autoantibodies on neuromuscular architecture

I Koneczny, R Herbst - Cells, 2019 - mdpi.com
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ).
Autoantibodies target key molecules at the NMJ, such as the nicotinic acetylcholine receptor …

Myasthenia gravis: autoantibody specificities and their role in MG management

K Lazaridis, SJ Tzartos - Frontiers in neurology, 2020 - frontiersin.org
Myasthenia gravis (MG) is the most common autoimmune disorder affecting the
neuromuscular junction, characterized by skeletal muscle weakness and fatigability. It is …

Clinical features of LRP4/agrin‐antibody–positive myasthenia gravis: A multicenter study

MH Rivner, BM Quarles, JX Pan, Z Yu… - Muscle & …, 2020 - Wiley Online Library
Introduction Our aim in this study was to identify the prevalence and clinical characteristics of
LRP4/agrin‐antibody–positive double‐seronegative myasthenia gravis (DNMG). Methods …

Clinical value of cell-based assays in the characterisation of seronegative myasthenia gravis

V Damato, G Spagni, G Monte, M Woodhall… - Journal of Neurology …, 2022 - jnnp.bmj.com
Objective Patients with myasthenia gravis without acetylcholine receptor (AChR) or muscle-
specific kinase (MuSK) antibodies detected by radioimmunoprecipitation assays (RIAs) are …

Amyotrophic lateral sclerosis survival associates with neutrophils in a sex-specific manner

BJ Murdock, SA Goutman, J Boss, S Kim… - Neurology …, 2021 - AAN Enterprises
Objective To determine whether neutrophils contribute to amyotrophic lateral sclerosis (ALS)
progression, we tested the association of baseline neutrophil count on ALS survival, whether …

Clinical features of myasthenia gravis with neurological and systemic autoimmune diseases

Y Zhu, B Wang, Y Hao, R Zhu - Frontiers in immunology, 2023 - frontiersin.org
Multiple reports on the co-existence of autoimmune diseases and myasthenia gravis (MG)
have raised considerable concern. Therefore, we reviewed autoimmune diseases in MG to …

Extrachromosomal circular DNA: current knowledge and implications for CNS aging and neurodegeneration

Q Ain, C Schmeer, D Wengerodt, OW Witte… - International journal of …, 2020 - mdpi.com
Still unresolved is the question of how a lifetime accumulation of somatic gene copy number
alterations impact organ functionality and aging and age-related pathologies. Such an issue …