Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

The ability to manipulate and sort droplets is a fundamental issue in droplet-based
microfluidics. Various lab-on-a-chip applications can only be realized if droplets are …

Measurement science has been converging to smaller and smaller samples, such that it is
now possible to detect single molecules. This Review focuses on the next generation of …

Circle-to-circle amplification (C2CA) is a specific and precise cascade nucleic acid
amplification method consisting of more than one round of padlock probe ligation and rolling …

The integration of nucleic acids detection assays in microfluidic devices represents a highly
promising approach for the development of convenient, cheap and efficient diagnostic tools …

Nucleic acid amplification techniques have always been one of the hot spots of research,
especially in the outbreak of COVID-19. From the initial polymerase chain reaction (PCR) to …

The global outbreaks of infectious diseases have significantly driven an imperative demand
for rapid and accurate molecular diagnostics. Nucleic acid amplification tests (NAATs) …

Conspectus The development of robust methods allowing the precise detection of specific
nucleic acid sequences is of major societal relevance, paving the way for significant …

The widespread dissemination of CTX-M extended spectrum β-lactamases among
Escherichia coli bacteria, both in nosocomial and community environments, is a challenge …

While LC-MS-based proteomics with high nanograms to micrograms of total protein has
become routine, the analysis of samples derived from low cell numbers is challenged by …