DNA-damage tolerance (DDT) is an important mechanism for living cells to bypass
replication blocks on the template strand. In Saccharomyces cerevisiae, DDT is mediated by …

Protein–DNA interactions can be characterized and quantified using single molecule
methods such as optical tweezers, magnetic tweezers, atomic force microscopy, and …

In yeast, ribosome production is controlled transcriptionally by tight coregulation of the 138
ribosomal protein genes (RPGs). RPG promoters display limited sequence homology, and …

The 137 ribosomal protein genes (RPGs) of Saccharomyces provide a model for gene
coregulation. We examined the positional and functional organization of their regulators …

HMG proteins are architectural proteins that bind to DNA with low sequence specificity, but
little is known about their genomic location and biological functions. Saccharomyces …

Specialized topoisomerases solve the topological constraints arising when replication forks
encounter transcription. We have investigated the contribution of Top2 in S phase …

Linker histone H1 plays a crucial role in various biological processes, including nucleosome
stabilization, high-order chromatin structure organization, gene expression, and epigenetic …

In eukaryotes, each of the more than 100 copies of ribosomal RNA (rRNA) genes exists in
either an RNA polymerase I transcribed open chromatin state or a nucleosomal, closed …

Ribosome biogenesis requires equimolar amounts of four rRNAs and all 79 ribosomal
proteins (RP). Coordinated regulation of rRNA and RP synthesis by eukaryotic RNA …

DNA replication is sensitive to damage in the template. To bypass lesions and complete
replication, cells activate recombination‐mediated (error‐free) and translesion synthesis …