Abstract Purpose of Review Type 2 diabetes (T2D) is a multifactorial, heritable syndrome
characterized by dysregulated glucose homeostasis that results from impaired insulin …

Pathogenic genetic variants (formerly called mutations) present in the germline of some
individuals are associated with a clinically relevant increased risk of developing lung cancer …

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …

Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …

We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of
PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …

Accurate colorectal cancer (CRC) risk prediction models are critical for identifying
individuals at low and high risk of developing CRC, as they can then be offered targeted …

Background It is proposed that, through restriction to individuals delineated as high risk,
polygenic risk scores (PRSs) might enable more efficient targeting of existing cancer …

To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an
extensive PRS online repository for 35 common cancer traits integrating freely available …

PURPOSE This study assessed the joint association of pathogenic variants (PVs) in breast
cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general …

Background Genetic variation increases the risk of lung cancer, but the extent to which
smoking amplifies this effect remains unknown. Therefore, we aimed to investigate the risk of …