Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …

Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …

Background Increasing the dose intensity of cytotoxic therapy by shortening the intervals
between cycles, or by giving individual drugs sequentially at full dose rather than in lower …

EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

Cancers are composed of populations of cells with distinct molecular and phenotypic
features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not …

Single-cell sequencing (SCS) is an emerging high-throughput technology that can be used
to study the genomics, transcriptomics, and epigenetics at a single cell level. SCS is widely …

Introduction Fibroblast activation protein-α (FAPα) is overexpressed on cancer-associated
fibroblasts in approximately 90% of epithelial neoplasms, representing an appealing target …

Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal
inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted and associated …

Abstract Treatment of advanced cancers has benefited from new agents that supplement or
bypass conventional therapies. However, even effective therapies fail as cancer cells deploy …