Multiphysics and multiscale modelling, data–model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics

R Chabiniok, VY Wang… - Interface …, 2016 - royalsocietypublishing.org
With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …

[HTML][HTML] Biomechanics of cardiac function

AP Voorhees, HC Han - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
The heart pumps blood to maintain circulation and ensure the delivery of oxygenated blood
to all the organs of the body. Mechanics play a critical role in governing and regulating heart …

A viscoelastic adhesive epicardial patch for treating myocardial infarction

X Lin, Y Liu, A Bai, H Cai, Y Bai, W Jiang… - Nature biomedical …, 2019 - nature.com
Acellular epicardial patches that treat myocardial infarction by increasing the mechanical
integrity of damaged left ventricular tissues exhibit widely scattered therapeutic efficacy …

Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments

M Genet, LC Lee, R Nguyen… - Journal of applied …, 2014 - journals.physiology.org
Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …

Modelling passive diastolic mechanics with quantitative MRI of cardiac structure and function

VY Wang, HI Lam, DB Ennis, BR Cowan… - Medical image …, 2009 - Elsevier
The majority of patients with clinically diagnosed heart failure have normal systolic pump
function and are commonly categorized as suffering from diastolic heart failure. The left …

In vivo three‐dimensional high resolution cardiac diffusion‐weighted MRI: a motion compensated diffusion‐prepared balanced steady‐state free precession approach

C Nguyen, Z Fan, B Sharif, Y He… - Magnetic resonance …, 2014 - Wiley Online Library
Purpose The aim of this study was to implement and optimize a novel application of diffusion‐
prepared balanced steady‐state free precession (bSSFP) to perform in vivo cardiac diffusion …

Digital image correlation and finite element modelling as a method to determine mechanical properties of human soft tissue in vivo

KM Moerman, CA Holt, SL Evans, CK Simms - Journal of biomechanics, 2009 - Elsevier
The mechanical properties of human soft tissue are crucial for impact biomechanics,
rehabilitation engineering, and surgical simulation. Validation of these constitutive models …

Parameter estimation in a Holzapfel–Ogden law for healthy myocardium

H Gao, WG Li, L Cai, C Berry, XY Luo - Journal of engineering …, 2015 - Springer
A central problem in biomechanical studies of personalized human left ventricular (LV)
modelling is to estimate material properties from in vivo clinical measurements. In this work …

First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation

JF Wenk, Z Zhang, G Cheng, D Malhotra… - The Annals of thoracic …, 2010 - Elsevier
BACKGROUND: Left ventricular remodeling after posterobasal myocardial infarction can
lead to ischemic mitral regurgitation. This occurs as a consequence of leaflet tethering due …

[HTML][HTML] Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy

J Yu, KL Christman, E Chin, RE Sievers… - The Journal of thoracic …, 2009 - Elsevier
OBJECTIVES: Various approaches to myocardial reconstruction have been developed for
the treatment of congestive heart failure resulting from ischemic cardiomyopathy …