Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

Aims/hypothesis: SGLT-2 inhibitors (SGLT-2i) have been studied as potential treatments
against NAFLD, showing varying beneficial effects. The molecular mechanisms mediating …

Abstract Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding
protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and …

Ulcerative colitis (UC), an etiologically complicated and relapsing gastrointestinal disease, is
characterized by the damage of mucosal epithelium and destruction of the intestinal …

The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …

Abstract Copper oxide nanoparticles (Nano-CuO) toxicity has been researched widely in
recent years. However, the relationship between oxidative stress and ER-stress and the …

In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive
transcriptional response sharing a signature of the integrated stress response (ISR) is …

Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Background: Large-scale human and mechanistic mouse studies indicate a strong
relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) …