The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Diabetic kidney disease is the most common cause of end-stage kidney disease and poses
a major global health problem. Finding new, safe, and effective strategies to halt this disease …

Background Inhibitors of the sodium-glucose cotransporter 2 (SGLT2) slow the progression
of diabetic kidney disease, possibly by reducing the proximal tubule transport workload with …

Tissue hypoxia plays a key role in the development and progression of many kidney
diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is …

Renal parenchymal hypoxia, documented under a variety of clinical conditions, conceivably
contributes to the progression chronic kidney disease. In this review, normal physiologic …

Renal tissue hypoperfusion and hypoxia are key elements in the pathophysiology of acute
kidney injury and its progression to chronic kidney disease. Yet, in vivo assessment of renal …

Atherosclerotic renal artery stenosis reduces blood flow and perfusion pressures to the
poststenotic kidney producing renovascular hypertension and threatening glomerular …

A key contributor to the progression of nearly all forms of CKD is fibrosis, a largely
irreversible process that drives further kidney injury. Despite its importance, clinicians …

Ultrasound and computed tomography (CT) are modalities of first choice in renal imaging.
Until now, magnetic resonance imaging (MRI) has mainly been used as a problem-solving …

Background Determinations of renal oxygenation by blood oxygenation level-dependent
magnetic resonance imaging (BOLD-MRI) in chronic kidney disease (CKD) patients have …