Pteridine nucleoside analog probes are highly fluorescent and offer different approaches to
monitor subtle DNA interactions with other molecules. Similarities in structure and size to …

The gel electrophoresis mobility shift assay (EMSA) is used to detect protein complexes with
nucleic acids. It is the core technology underlying a wide range of qualitative and …

Transcription of genes during development and in response to environmental stimuli is
determined by genomic DNA sequence. The DNA sequences regulating transcription are …

The monoclonal antibody S9. 6 is a widely-used tool to purify, analyse and quantify R-loop
structures in cells. A previous study using the surface plasmon resonance technology and a …

Mitochondrial transcription factor A (TFAM) plays a critical role in mitochondrial transcription
initiation and mitochondrial DNA (mtDNA) packaging. Both functions require DNA binding …

Human clinical isolates of Staphylococcus aureus, for example, strains Newman and N315,
cannot grow in the absence of proline, albeit their sequenced genomes harbor genes for two …

Protein− DNA/protein− protein interactions play critical roles in many biological processes.
We report here the investigation of protein− protein interactions using molecular aptamers …

Many RNA viruses are detected by retinoic acid-inducible gene i (RIG-I), a cytoplasmic
sensor that triggers an antiviral response upon binding non-self-RNA that contains a stretch …

HU, a nonspecific histone-like DNA binding protein, participates in a number of genomic
events as an accessory protein and forms multiple complexes with DNA. The HU− DNA …

In the initiation of bacterial DNA replication, DnaA protein recruits DnaB helicase to the
chromosomal origin, oriC, leading to the assemble of the replication fork machinery at this …