In vitro digestion models are widely used to study the structural changes, digestibility, and
release of food components under simulated gastrointestinal conditions. However, the …

The bioavailability of an orally administered small molecule is often dictated by drug-specific
physicochemical characteristics and is influenced by many biological processes. For …

In vitro cell culture models for studying oral drug absorption during early stages of drug
development have become a useful tool in drug discovery and development, with respect to …

As a consequence of modern drug discovery techniques, there has been a consistent
increase in the number of new pharmacologically active lipophilic compounds that are …

The large number of drug candidates with poor dissolution characteristics seen in the past
decade, has fostered interest in so-called “enabling formulations”, ie, formulations which …

Surfactants are a diverse group of compounds that share the capacity to adsorb at the
boundary between distinct phases of matter. They are used as pharmaceutical excipients …

During the past two decades, a range of in vitro models simulating the digestion processes
occurring in the stomach and small intestine have been developed to characterize lipid …

Biorelevant media are commonly used to simulate the physiological composition of human
intestinal fluids (HIF) in in vitro solubility and dissolution investigations. In comparison with …

The application of in vitro models in drug permeability studies represents a useful screening
tool for assessing the biopharmaceutical appropriateness of new chemical entities (NCEs) …

Various methods of sampling and analyzing intestinal fluids have been applied over the
years. In this report, data that have been published to date about the composition of fasted …