MHC class II molecules on the surface of antigen-presenting cells display a range of
peptides for recognition by the T-cell receptors of CD4+ T helper cells. Therefore, MHC class …

The 18.5 kDa isoform of myelin basic protein (MBP) is a major component of the myelin
sheath in the central nervous system of higher vertebrates, and a member of a larger family …

The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …

Susceptibility and protection against human autoimmune diseases, including type I
diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human …

The multiple sclerosis (MS)-associated HLA major histocompatibility complex (MHC) class II
alleles DRB1* 1501, DRB5* 0101 and DQB1* 0602 are in strong linkage disequilibrium …

The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2
in humans and IA g7 in nonobese diabetic (NOD) mice are the major risk factors for …

Mass spectrometry (MS) based immunopeptidomics is used in several biomedical
applications including neo-epitope discovery in oncology, next-generation vaccine …

Over the past several years, there have been remarkable advances in our understanding of
how commensal organisms shape host immunity. Although the full cast of immunogenic …

Little is known about the processing of putative human autoantigens and why tolerance is
established to some T cell epitopes but not others. Here we show that a principal human …

The development of epitope-based vaccines, which have wide population coverage, is
greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the …