G Harauz, N Ishiyama, CMD Hill, IR Bates, DS Libich… - Micron, 2004 - Elsevier
The 18.5 kDa isoform of myelin basic protein (MBP) is a major component of the myelin sheath in the central nervous system of higher vertebrates, and a member of a larger family …
J Wang, I Jelcic, L Mühlenbruch, V Haunerdinger… - Cell, 2020 - cell.com
The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …
Susceptibility and protection against human autoimmune diseases, including type I diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human …
HLE Lang, H Jacobsen, S Ikemizu, C Andersson… - Nature …, 2002 - nature.com
The multiple sclerosis (MS)-associated HLA major histocompatibility complex (MHC) class II alleles DRB1* 1501, DRB5* 0101 and DQB1* 0602 are in strong linkage disequilibrium …
The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and IA g7 in nonobese diabetic (NOD) mice are the major risk factors for …
S Kaabinejadian, C Barra, B Alvarez, H Yari… - Frontiers in …, 2022 - frontiersin.org
Mass spectrometry (MS) based immunopeptidomics is used in several biomedical applications including neo-epitope discovery in oncology, next-generation vaccine …
Over the past several years, there have been remarkable advances in our understanding of how commensal organisms shape host immunity. Although the full cast of immunogenic …
B Manoury, D Mazzeo, L Fugger, N Viner… - Nature …, 2002 - nature.com
Little is known about the processing of putative human autoantigens and why tolerance is established to some T cell epitopes but not others. Here we show that a principal human …
IA Doytchinova, DR Flower - The Journal of Immunology, 2005 - journals.aai.org
The development of epitope-based vaccines, which have wide population coverage, is greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the …