Bacterial quorum sensing in complex and dynamically changing environments

S Mukherjee, BL Bassler - Nature Reviews Microbiology, 2019 - nature.com
Quorum sensing is a process of bacterial cell-to-cell chemical communication that relies on
the production, detection and response to extracellular signalling molecules called …

Progress in and promise of bacterial quorum sensing research

M Whiteley, SP Diggle, EP Greenberg - Nature, 2017 - nature.com
This Review highlights how we can build upon the relatively new and rapidly developing
field of research into bacterial quorum sensing (QS). We now have a depth of knowledge …

Quorum-sensing systems as targets for antivirulence therapy

T Defoirdt - Trends in microbiology, 2018 - cell.com
The development of novel therapies to control diseases caused by antibiotic-resistant
pathogens is one of the major challenges we are currently facing. Many important plant …

The rebirth of culture in microbiology through the example of culturomics to study human gut microbiota

JC Lagier, P Hugon, S Khelaifia… - Clinical microbiology …, 2015 - Am Soc Microbiol
Bacterial culture was the first method used to describe the human microbiota, but this
method is considered outdated by many researchers. Metagenomics studies have since …

Exploiting quorum sensing to confuse bacterial pathogens

B LaSarre, MJ Federle - Microbiology and molecular biology …, 2013 - Am Soc Microbiol
Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that
is used to coordinate gene expression among local populations. Its use by bacterial …

Evolution of the Pseudomonas aeruginosa quorum-sensing hierarchy

M Kostylev, DY Kim, NE Smalley… - Proceedings of the …, 2019 - National Acad Sciences
The bacterial pathogen Pseudomonas aeruginosa activates expression of many virulence
genes in a cell density-dependent manner by using an intricate quorum-sensing (QS) …

Targeting virulence: can we make evolution-proof drugs?

RC Allen, R Popat, SP Diggle, SP Brown - Nature Reviews Microbiology, 2014 - nature.com
Antivirulence drugs are a new type of therapeutic drug that target virulence factors,
potentially revitalising the drug-development pipeline with new targets. As antivirulence …

Acyl-homoserine lactone quorum sensing: from evolution to application

M Schuster, D Joseph Sexton, SP Diggle… - Annual review of …, 2013 - annualreviews.org
Quorum sensing (QS) is a widespread process in bacteria that employs autoinducing
chemical signals to coordinate diverse, often cooperative activities such as …

Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung

K Zhao, X Yang, Q Zeng, Y Zhang, H Li, C Yan… - Nature …, 2023 - nature.com
Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to
coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of …

Quorum sensing for population-level control of bacteria and potential therapeutic applications

S Wu, J Liu, C Liu, A Yang, J Qiao - Cellular and Molecular Life Sciences, 2020 - Springer
Quorum sensing (QS), a microbial cell-to-cell communication process, dynamically regulates
a variety of metabolism and physiological activities. In this review, we provide an update on …