The discovery of glucagon-like peptide-1 (GLP-1), an incretin hormone with important effects
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …

The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

Abstract Glucagon-like peptide 1 (GLP-1) is a hormone with essential roles in regulating
insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated …

The class B glucagon-like peptide-1 (GLP-1) G protein-coupled receptor is a major target for
the treatment of type 2 diabetes and obesity. Endogenous and mimetic GLP-1 peptides …

Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple
diseases; however, there remains substantial interest in the development of orally delivered …

The glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are
members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and …

Abstract Glucagon-like peptide 1 (GLP-1) regulates glucose homeostasis through the control
of insulin release from the pancreas. GLP-1 peptide agonists are efficacious drugs for the …

Abstract Glucagon-like peptide-1 receptor (GLP-1R) is a class BG protein-coupled receptor
that plays an important role in glucose homeostasis and treatment of type 2 diabetes …

The secretin-like class B family of G protein-coupled receptors (GPCRs) are key players in
hormonal homeostasis. Recent structures of various receptors in complex with a variety of …

Class B G-protein-coupled receptors (GPCRs), which consist of an extracellular domain
(ECD) and a transmembrane domain (TMD), respond to secretin peptides to play a key part …