NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability,
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few
of these kinases are currently known to enable learning and memory. Based on this …

The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

Schizophrenia is a disabling mental illness that is now recognized as a neurodevelopmental
disorder. It is likely that genetic risk factors interact with environmental perturbations to affect …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC)
synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, the underlying …

The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine
kinase, which senses and integrates several intracellular and environmental cues to …

The prefrontal cortex (PFC), seat of the highest-order cognitive functions, constitutes a
conglomerate of highly specialized brain areas and has been implicated to have a role in …

Intense research on the pathogenesis of Huntington's disease (HD), a genetic
neurodegenerative disease caused by a polyglutamine expansion in the Huntingtin (Htt) …