[HTML][HTML] Pros and cons of different therapeutic antibody formats for recombinant antivenom development

AH Laustsen, JM Gutiérrez, C Knudsen, KH Johansen… - Toxicon, 2018 - Elsevier
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by
the many advances in immunology, synthetic biology, and antibody research, different …

Protein scaffolds: antibody alternatives for cancer diagnosis and therapy

R Luo, H Liu, Z Cheng - RSC chemical biology, 2022 - pubs.rsc.org
Although antibodies are well developed and widely used in cancer therapy and diagnostic
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …

Guiding recombinant antivenom development by omics technologies

AH Laustsen - New biotechnology, 2018 - Elsevier
In this review, the different approaches that have been employed with the aim of developing
novel antivenoms against animal envenomings are presented and discussed. Reported …

Antibody engineering for nuclear imaging and radioimmunotherapy

C Rodriguez, S Delaney, SM Sarrett… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Radiolabeled antibodies have become indispensable tools in nuclear medicine. However,
the natural roles of antibodies within the immune system mean that they have several …

Synthetic antibody mimics for the inhibition of protein–ligand interactions

C Haußner, J Lach, J Eichler - Current opinion in chemical biology, 2017 - Elsevier
Highlights•Antibody fragments retain the binding characteristics of the complete
antibody.•Non-antibody protein scaffolds with loops serve as alternative binding …

PyFolding: open-source graphing, simulation, and analysis of the biophysical properties of proteins

AR Lowe, A Perez-Riba, LS Itzhaki, ERG Main - Biophysical Journal, 2018 - cell.com
For many years, curve-fitting software has been heavily utilized to fit simple models to
various types of biophysical data. Although such software packages are easy to use for …

Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding

AR Sirois, DA Deny, SR Baierl, KS George, SJ Moore - Plos one, 2018 - journals.plos.org
Mesothelin is a cell surface protein that is overexpressed in numerous cancers, including
breast, ovarian, lung, liver, and pancreatic tumors. Aberrant expression of mesothelin has …

[HTML][HTML] Frontier Views in Designing Therapeutic Candidates for Management of Diverse Diseases

MA Kamal, NH Greig - Current pharmaceutical design, 2017 - ncbi.nlm.nih.gov
There is little doubt that humanity is still suffering from a huge burden of health issues in
today's era of sophisticated technology and medical sciences, such as cancer, obesity …

Age-Related Macular Degeneration

J Hellman, G Yiu - Vitreoretinal Disorders, 2018 - Springer
Age-related macular degeneration (AMD) is one of the major causes of vision loss in the
elderly, manifesting as either nonexudative “dry” or exudative “wet” AMD. Although the …

[PDF][PDF] WC1H 0AH, UK

AR Lowe, A Perez-Riba, LS Itzhaki, ERG Main - core.ac.uk
For many years, curve fitting software has been heavily utilized to fit simple models to
various types of biophysical data. Although such software packages are easy to use for …