The role of γ-aminobutyric acid (GABA) as a signal in animals has been documented for
over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the …

The transmitter-gated ion channels mediate rapid synaptic transmission, for example, at the
neuromuscular junction using acetylcholine and in the CNS using primarily the amino acids …

The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor
superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective …

GABA is the main inhibitory neurotransmitter in the mammalian brain. The postsynaptic
GABAA receptor/pore complex is presumed to be a pentamer typically composed of a …

1 Wild‐type and mutant α1β2γ2 GABAA receptors were expressed in Xenopus laevis
oocytes and examined using the two‐electrode voltage clamp. 2 Dose–response …

The γ‐aminobutyric acid type A (GABAA) receptor represents an elementary switching
mechanism integral to the functioning of the central nervous system and a locus for the …

Identification of all residues involved in the recognition and binding of cholinergic ligands
(eg agonists, competitive antagonists, and noncompetitive agonists) is a primary objective to …

Two alleles of the HG1 gene, which encodes a putative GABA receptor α/γ subunit, were
isolated from Haemonchus contortus. These two alleles were shown previously to be …

An amino acid which appears to be involved in an agonist binding site of the gamma-
aminobutyric acid type A (GABAA) receptor protein has been identified by photoaffinity …

A conserved leucine residue in the midpoint of the second transmembrane domain (M2) of
the ligand-activated ion channel family has been proposed to play an important role in …