Unlocking the potential of microfluidics in mass spectrometry-based immunopeptidomics for tumor antigen discovery
The identification of tumor-specific antigens (TSAs) is critical for developing effective cancer
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …
[HTML][HTML] The biogenesis of the immunopeptidome
A Admon - Seminars in Immunology, 2023 - Elsevier
The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …
I, class II, and non-classical molecules. The peptides are produced by the degradation of …
Using mass spectrometry to identify neoantigens in autoimmune diseases: the type 1 diabetes example
In autoimmune diseases, recognition of self-antigens presented by major histocompatibility
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …
Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines
KA Kovalchik, DJ Hamelin, P Kubiniok… - Nature …, 2024 - nature.com
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell
immunity against current and emerging SARS-CoV-2 variants. Precise identification of …
immunity against current and emerging SARS-CoV-2 variants. Precise identification of …
Integrating Machine Learning-Enhanced Immunopeptidomics and SARS-CoV-2 Population-Scale Analyses Unveils Novel Antigenic Features for Next-Generation …
Next-generation T-cell-directed vaccines for COVID-19 aim to induce durable T-cell
immunity against circulating and future hypermutated SARS-CoV-2 variants. Mass …
immunity against circulating and future hypermutated SARS-CoV-2 variants. Mass …