Chemical strategies to engineer hydrogels for cell culture

J Lou, DJ Mooney - Nature Reviews Chemistry, 2022 - nature.com
Two-dimensional and three-dimensional cell culture systems are widely used for biological
studies, and are the basis of the organoid, tissue engineering and organ-on-chip research …

Effects of extracellular matrix viscoelasticity on cellular behaviour

O Chaudhuri, J Cooper-White, PA Janmey, DJ Mooney… - Nature, 2020 - nature.com
Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

Hydrogel scaffolds for tissue engineering: the importance of polymer choice

CD Spicer - Polymer Chemistry, 2020 - pubs.rsc.org
Hydrogel scaffolds that can repair or regrow damaged biological tissue have great potential
for the treatment of injury and disease. These biomaterials are widely used in the tissue …

Toward stimuli‐responsive dynamic thermosets through continuous development and improvements in covalent adaptable networks (CANs)

M Podgórski, BD Fairbanks, BE Kirkpatrick… - Advanced …, 2020 - Wiley Online Library
Covalent adaptable networks (CANs), unlike typical thermosets or other covalently
crosslinked networks, possess a unique, often dormant ability to activate one or more forms …

Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues

S Tang, BM Richardson, KS Anseth - Progress in Materials Science, 2021 - Elsevier
The extracellular matrix (ECM) and its mechanical properties play an important role in
regulating the cellular responses that occur during tissue regeneration, wound healing, and …

Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms

FJ Vernerey, S Lalitha Sridhar, A Muralidharan… - Chemical …, 2021 - ACS Publications
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Dynamic covalent bonds in self-healing, shape memory, and controllable stiffness hydrogels

MM Perera, N Ayres - Polymer Chemistry, 2020 - pubs.rsc.org
Emerging technologies are increasingly reliant on materials that deliver multiple
functionality. For example, hydrogels using dynamic covalent crosslinks have proven well …

Dynamic bioinks to advance bioprinting

FLC Morgan, L Moroni, MB Baker - Advanced healthcare …, 2020 - Wiley Online Library
The development of bioinks for bioprinting of cell‐laden constructs remains a challenge for
tissue engineering, despite vigorous investigation. Hydrogels to be used as bioinks must …

Viscoelastic cell microenvironment: hydrogel‐based strategy for recapitulating dynamic ECM mechanics

Y Ma, T Han, Q Yang, J Wang, B Feng… - Advanced Functional …, 2021 - Wiley Online Library
The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Designing hydrogels for 3D cell culture using dynamic covalent crosslinking

M Rizwan, AEG Baker… - Advanced Healthcare …, 2021 - Wiley Online Library
Designing simple biomaterials to replicate the biochemical and mechanical properties of
tissues is an ongoing challenge in tissue engineering. For several decades, new …