Pancreatic cancer chemoresistance to gemcitabine

M Amrutkar, IP Gladhaug - Cancers, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer,
ranks among the leading causes of cancer-related deaths in the Western world due to …

Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)

CW Schultz, R Preet, T Dhir, DA Dixon… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

[HTML][HTML] Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis

J Wang, Y Guo, H Chu, Y Guan, J Bi… - International journal of …, 2013 - mdpi.com
The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …

Gemcitabine: a review of chemoresistance in pancreatic cancer

D Sarvepalli, MU Rashid, AU Rahman… - Critical Reviews™ in …, 2019 - dl.begellhouse.com
Pancreatic ductal adenocarcinoma, an exocrine tumor, is the most common type of cancer of
the pancreas and one of the top five most prominent causes of cancer-associated mortality …

Targeting the RNA-binding protein HuR in cancer

JM Finan, TL Sutton, DA Dixon, JR Brody - Cancer Research, 2023 - AACR
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

R Muralidharan, M Mehta, R Ahmed, S Roy, L Xu… - Scientific reports, 2017 - nature.com
Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer
correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has …

HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …

Overcoming nucleoside analog chemoresistance of pancreatic cancer: a therapeutic challenge

SW Hung, HR Mody, R Govindarajan - Cancer letters, 2012 - Elsevier
Clinical refractoriness to nucleoside analogs (eg, gemcitabine, capecitabine) is a major
scientific problem and is one of the main reasons underlying the extremely poor prognostic …

Clinical significance of HuR expression in human malignancy

I Kotta-Loizou, C Giaginis, S Theocharis - Medical oncology, 2014 - Springer
Hu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and
nucleus-to-cytoplasm translocation of target mRNAs. The aim of the present review was to …

XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)

GL Gravina, M Tortoreto, A Mancini, A Addis… - Journal of hematology & …, 2014 - Springer
Abstract Background Exportin 1 (XPO1), also called chromosome region maintenance 1
(CRM1), is the sole exportin mediating transport of many multiple tumor suppressor proteins …