The monoamine hypothesis has been accepted as the most common hypothesis of major
depressive disorder (MDD) for a long period because of its simplicity and understandability …

Sleep is highly conserved across evolution, suggesting vital biological functions that are yet
to be fully understood. Animals and humans experiencing partial sleep restriction usually …

For many years, researchers have suggested that abnormalities in circadian rhythms may
underlie the development of mood disorders such as bipolar disorder (BPD), major …

Sleep–wake disturbances following traumatic brain injury (TBI) are increasingly recognized
as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep …

The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular
zone of the dentate gyrus is regulated negatively by stressful experiences and positively by …

Several lines of evidence suggest that adult neurogenesis, the production of new neurons in
adulthood, may play a role in psychiatric disorders, including depression, anxiety, and …

The function (s) of sleep remains a major unanswered question in biology. We assessed
changes in gene expression in the mouse cerebral cortex and hypothalamus following …

The focus of this review is on driving neuroplasticity in a positive direction using evidence-
based interventions that also have the potential to improve general health. One goal is to …

Currently available antidepressants used to treat major depressive disorder (MDD)
unfortunately often take weeks to months to achieve their full effects, commonly resulting in …

Individuals are increasingly exposed to light at night. Exposure to constant light (LL) disrupts
circadian rhythms of locomotor activity, body temperature, hormones, and the sleep-wake …