Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive
complex 2 (PRC2), has attracted broad research attention in the past few years because of …

Polycomb group proteins maintain the gene-expression pattern of different cells that is set
during early development by regulating chromatin structure. In mammals, two main …

The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of
genes that control cell identity and repression of genes encoding lineage-specifying …

Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-
seq) has become a valuable and widely used approach for mapping the genomic location of …

Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …

Motivation: Recently there has been increasing interest in the effects of cell mixture on the
measurement of DNA methylation, specifically the extent to which small perturbations in cell …

Histone modifications are implicated in influencing gene expression. We have generated
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …

Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood.
Here we characterize the transcriptional landscape of the four human HOX loci at five base …

We report the application of single-molecule-based sequencing technology for high-
throughput profiling of histone modifications in mammalian cells. By obtaining over four …

Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …