Monocytes and macrophages are central players of the innate immune response and play a
pivotal role in the regulation of inflammation. Thereby, they actively participate in all phases …

Neutrophils and monocytes belong to the first line of immune defence cells and are recruited
to sites of inflammation during infection or sterile injury. Both cells contain huge amounts of …

S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to
play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the …

Abstract S100A8 and S100A9 are small calcium-binding proteins that are highly expressed
in neutrophil and monocyte cytosol and are found at high levels in the extracellular milieu …

The S100 family of calcium binding proteins contains approximately 16 members each of
which exhibits a unique pattern of tissue/cell type specific expression. Although the …

Abstract S100A8/A9, also known as “calprotectin” or “MRP8/14,” is an alarmin primarily
secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic …

Summary Calprotectin (MRP8/14, S100A8/S100A9, 27E10 antigen) is a heterodimer of two
calcium-binding proteins present in the cytoplasm of neutrophils and expressed on the …

Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Current evidence supports that inflammation is a major driving force underlying the initiation
of coronary plaques, their unstable progression, and eventual disruption; patients with a …

The S100 family of EF-hand calcium (Ca 2+)-binding proteins is essential for a wide range of
cellular functions. During infection, certain S100 proteins act as damage-associated …