Fibrosis is the extensive deposition of fibrous connective tissue, and it is characterized by
the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is …

Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …

Fibrosis is a common pathological response to inflammation in many peripheral tissues and
can prevent tissue regeneration and repair. Here, we identified persistent fibrotic scarring in …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Radiation therapy has curative or palliative potential in roughly half of all incident solid
tumours, and offers organ and function preservation in most cases. Unfortunately, early and …

Different animal models of pulmonary fibrosis have been developed to investigate potential
therapies for idiopathic pulmonary fibrosis (IPF). The most common is the bleomycin model …

Fibrosis is the production of excessive amounts of connective tissue, ie, scar formation, in
the course of reactive and reparative processes. Fibrosis develops as a consequence of …

Tissue injury and inflammatory response trigger the development of fibrosis in various
diseases. It has been recognized that both innate and adaptive immune cells are important …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Fibrosis is an important health problem, and its pathogenetic principles are still largely
unknown. It can develop either spontaneously, or, more frequently, as a consequence of …