The transcriptional factor NF-κB is a nuclear factor involved in both physiological and
pathological processes. This factor can control the transcription of more than 400 genes …

Apicomplexans are a group of pathogenic protists that cause various diseases in humans
and animals that cause economic losses worldwide. These unicellular eukaryotes are …

Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum
Apicomplexa. It has a worldwide distribution and can infect a wide variety of intermediate …

In human congenital toxoplasmosis the effects of parasite burden and pregnancy time at
infection on clinical outcome are well known, but there is controversy regarding the role of …

Molecular communication between a pathogen and its host is crucial for a successful
interplay. Extracellular vesicles (EVs) act as mediators for the delivery of molecular signals …

As an immune-privileged organ, the placenta can tolerate the introduction of antigens
without inducing a strong inflammatory response that would lead to abortion. However, for …

TORCH pathogens are a group of globally prevalent infectious agents that may cross the
placental barrier, causing severe negative sequalae in neonates, including fetal death and …

Toxoplasma gondii is the protozoan causative agent of toxoplasmosis in humans and warm-
blooded animals. Recent studies have illustrated that the immune system plays a pivotal role …

Toxoplasma gondii is an obligate intracellular parasite of phylum Apicomplexa that poses a
huge threat to pregnant hosts, and induces tragic outcomes for pregnant hosts, fetuses and …

Due to the lack of efficient antiparasitic therapy and vaccines, as well as emerging
resistance strains, congenital toxoplasmosis is still a public health issue worldwide. The …