Child health, developmental plasticity, and epigenetic programming

Z Hochberg, R Feil, M Constancia, M Fraga… - Endocrine …, 2011 - academic.oup.com
Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

SJ Scales, FJ de Sauvage - Trends in pharmacological sciences, 2009 - cell.com
The Hedgehog (Hh) signaling pathway regulates body patterning and organ development
during embryogenesis. In adults the Hh pathway is mainly quiescent, with the exception of …

High-resolution analysis of parent-of-origin allelic expression in the mouse brain

C Gregg, J Zhang, B Weissbourd, S Luo, GP Schroth… - science, 2010 - science.org
Genomic imprinting results in preferential expression of the paternal or maternal allele of
certain genes. We have performed a genome-wide characterization of imprinting in the …

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

NR Sundaresan, P Vasudevan, L Zhong, G Kim… - Nature medicine, 2012 - nature.com
Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the
development of various diseases, including heart failure. However, the molecular …

Age-related macular degeneration revisited–piecing the puzzle: the LXIX Edward Jackson memorial lecture

JW Miller - American journal of ophthalmology, 2013 - Elsevier
PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging

S Halfon, N Abramov, B Grinblat… - Stem cells and …, 2011 - liebertpub.com
Expansion of plastic-adherent bone marrow-derived mesenchymal stem cells (MSCs)
results in gradual loss of osteogenic potential after passage 5–6. One explanation is …

Insulin-like growth factor 2 in development and disease: a mini-review

D Bergman, M Halje, M Nordin, W Engström - Gerontology, 2013 - karger.com
Background: Insulin-like growth factor 2 (IGF2) is a protein hormone known to regulate cell
proliferation, growth, migration, differentiation and survival. The gene is parentally imprinted …

Paternal obesity is associated with IGF2hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort

A Soubry, JM Schildkraut, A Murtha, F Wang, Z Huang… - BMC medicine, 2013 - Springer
Background Data from epidemiological and animal model studies suggest that nutrition
during pregnancy may affect the health status of subsequent generations. These …

Resveratrol: its biologic targets and functional activity

S Pervaiz, AL Holme - Antioxidants & redox signaling, 2009 - liebertpub.com
Abstract 2852 The polyphenolic phytoalexin resveratrol (RSV) and its analogues have
received tremendous attention over the past couple of decades because of a number of …

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks

AM Newman, NB Gallo, LS Hancox, NJ Miller… - Genome medicine, 2012 - Springer
Background Age-related macular degeneration (AMD) is a leading cause of blindness that
affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural …