Within the past 2 years, several angiogenic factors have been fully purified, their amino acid
sequences determined, and their genes cloned. These polypeptides include acidic and …

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine
pituitary folliculostellate cells (FC). VEGF is a heparin-binding growth factor specific for …

Multiple macrophage products Paradoxically, the list of macrophage secretory products
(Table I) has not grown much longer in the lastfew years, despite con-tinual entries. The …

When tissue loss disrupts normal architecture in higher vertebrate adult animals, the organ
fails to regenerate. Instead, repair proceeds as a fibroproliferative response that develops …

Angiogenesis is critical to wound repair. Newly formed blood vessels participate in
provisional granulation tissue formation and provide nutrition and oxygen to growing tissues …

Macrophages are important in the induction of new blood vessel growth during wound
repair, inflammation and tumour growth1–4. We show here that tumour necrosis factor-α …

Recent studies have focused on the potential role of transforming growth factor type beta
(TGF-beta) as an immunoregulatory peptide. In this context, we demonstrate that TGF-beta is …

The presence of macrophages is required for the regeneration of many cell types during
wound healing. Macrophages have been reported to express a wide range of mitogenic …

The contraction of granulation tissue from skin wounds was first described in the 1960s.
Later it was discovered that during tissue repair, fibroblasts undergo a change in phenotype …