The classical view of the structure–function paradigm advanced by Anfinsen in the 1960s is
that a protein's function is inextricably linked to its three‐dimensional structure and is …

Proteins form arguably the most significant link between genotype and phenotype.
Understanding the relationship between protein sequence and structure, and applying this …

A central tenet of biology is that globular proteins have a unique 3D structure under
physiological conditions. Recent work has challenged this notion by demonstrating that …

A study of the mechanisms of pearlite spheroidization under static annealing conditions was
carried out in two materials—AISI 1080 steel and pure Fe-C alloy. By electrolytically etching …

Folded proteins are assumed to be built upon fixed scaffolds of secondary structure, α-
helices and β-sheets. Experimentally determined structures of> 58,000 non-redundant …

Naturally occurring metamorphic proteins have the ability to interconvert from one folded
state to another through either a limited set of mutations or by way of a change in the local …

Although homologous protein sequences are expected to adopt similar structures, some
amino acid substitutions can interconvert α-helices and β-sheets. Such fold switching may …

Four de novo proteins differing in single mutation positions, with a chain length of 56 amino
acids, represent diverse 3D structures: monomeric 3α and 4β+ α folds. The reason for this …

Most foldable protein sequences adopt only a single native fold. Recent protein design
studies have, however, created protein sequences which fold into different structures apon …

RfaH is a compact two‐domain bacterial transcription factor that functions both as a
regulator of transcription and an enhancer of translation. Underpinning the dual functional …