[HTML][HTML] Multiple sclerosis incidence: a systematic review of change over time by geographical region

J Lane, HS Ng, C Poyser, RM Lucas… - Multiple Sclerosis and …, 2022 - Elsevier
Background The incidence of multiple sclerosis (MS) has reportedly increased over time;
however, change in MS incidence has not been rigorously assessed globally. Methods We …

Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection

AK Hedström - Frontiers in Immunology, 2023 - frontiersin.org
Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for
multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV …

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update …

RE Neale, PW Barnes, TM Robson, PJ Neale… - Photochemical & …, 2021 - Springer
This assessment by the Environmental Effects Assessment Panel (EEAP) of the United
Nations Environment Programme (UNEP) provides the latest scientific update since our …

Adaptive immunity, chronic inflammation and the clock

KJ Gray, JE Gibbs - Seminars in Immunopathology, 2022 - Springer
The adaptive arm of the immune system facilitates recognition of specific foreign pathogens
and, via the action of T and B lymphocytes, induces a fine-tuned response to target the …

A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

L Hauer, J Perneczky, J Sellner - Journal of Neurology, 2021 - Springer
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system
which is associated with numerous comorbidities. These include cardiovascular disease …

Vitamin D as a risk factor for multiple sclerosis: immunoregulatory or neuroprotective?

SE Gombash, PW Lee, E Sawdai… - Frontiers in …, 2022 - frontiersin.org
Vitamin D insufficiency during childhood has been linked to the development of multiple
sclerosis (MS), typically an adult-onset inflammatory demyelinating disease of the central …

The latitude gradient for multiple sclerosis prevalence is established in the early life course

CE Sabel, JF Pearson, DF Mason, E Willoughby… - Brain, 2021 - academic.oup.com
The strongest epidemiological clue that the environment at the population level has a
significant impact on the risk of developing multiple sclerosis is the well established, and in …

Melatonin and vitamin D, two sides of the same coin, better to land on its edge to improve multiple sclerosis

M Ghareghani, K Zibara… - Proceedings of the …, 2023 - National Acad Sciences
Previous studies revealed a latitudinal gradient of multiple sclerosis (MS) prevalence,
increasing by moving from the equator to the poles. The duration and quality of an …

Shared Genetic Risk Factors for Multiple Sclerosis/Psoriasis Suggest Involvement of Interleukin‐17 and Janus Kinase–Signal Transducers and Activators of …

MT Patrick, RP Nair, K He, PE Stuart, AC Billi… - Annals of …, 2023 - Wiley Online Library
Objective Psoriasis and multiple sclerosis (MS) are complex immune diseases that are
mediated by T cells and share multiple comorbidities. Previous studies have suggested …

Vitamin D did not reduce multiple sclerosis disease activity after a clinically isolated syndrome

H Butzkueven, AL Ponsonby, MS Stein, RM Lucas… - Brain, 2024 - academic.oup.com
Low serum levels of 25-hydroxyvitamin D [25 (OH) D] and low sunlight exposure are known
risk factors for the development of multiple sclerosis. Add-on vitamin D supplementation …