Endothelins (ETs) were initially thought to be primarily involved in the control of
cardiovascular activity, but the presence of ETs and their receptors in a wide variety of other …

Background and Purpose—While it has been widely reported that the vasospasm following
subarachnoid hemorrhage (SAH) is prevented/reversed by endothelin (ET) receptor …

Objective Scavenging of vascular endothelial growth factor (VEGF) elevates blood pressure
(BP) in patients receiving anti-angiogenic therapy. Similarly, inhibition of circulation VEGF by …

1 The pharmacology and mRNA expression of endothelin (ET) receptors in human omental
arteries were characterized by use of functional contractile assays and the reverse …

The clinical efficiency of the highly potent antitumor agent doxorubicin is limited by
cardiotoxic effects. In a murine doxorubicin cardiotoxicity model, increased endothelin-1 (ET …

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that has been widely known as
a pain mediator involved in various pain states. Evidence indicates that ET-1 sensitizes …

The human brain requires adequate cerebral blood flow to meet the high demand for
nutrients and to clear waste products. With age, there is a chronic reduction in cerebral …

We used Ro 46‐8443, non‐peptidic antagonist selective of endothelin ETB receptors, to
study the role of ETB receptors in rat hypertension models. In normotensive rats, Ro 46 …

Endothelin (ET) is a potent vasoconstrictor peptide which has been shown to have an
important role in the regulation of systemic and renal haemodynamics. In order to elucidate …

The functional importance of endothelin ETA and ETB receptors in selected arterial and
venous smooth muscle preparations was characterized. Endothelin-1 induced force in the …