The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

Precisely controlled cell deformations are key to cell migration, division and tissue
morphogenesis, and have been implicated in cell differentiation during development, as well …

INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …

Intestinal organoids derived from single cells undergo complex crypt–villus patterning and
morphogenesis. However, the nature and coordination of the underlying forces remains …

Muscle stem cells (MuSCs) are essential for tissue homeostasis and regeneration, but the
potential contribution of MuSC morphology to in vivo function remains unknown. Here, we …

Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

The mechanical behaviour of cells is largely controlled by a structure that is fundamentally
out of thermodynamic equilibrium: a network of crosslinked filaments subjected to the action …

Tissue morphogenesis, homoeostasis and repair require cells to constantly monitor their
three-dimensional microenvironment and adapt their behaviours in response to local …

Cell-cell junctions respond to mechanical forces by changing their organization and
function. To gain insight into the mechanochemical basis underlying junction …