Microfluidic organoids-on-a-chip: Quantum leap in cancer research

F Duzagac, G Saorin, L Memeo, V Canzonieri… - Cancers, 2021 - mdpi.com
Simple Summary Organoids, also known as self-organized 3D organ-like clusters, represent
almost a physiological system for studying cells, stem cells, tissues, and diseases, especially …

[HTML][HTML] Non-small molecule PROTACs (NSM-PROTACs): protein degradation kaleidoscope

S Ma, J Ji, Y Tong, Y Zhu, J Dou, X Zhang, S Xu… - … Pharmaceutica Sinica B, 2022 - Elsevier
The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed
since its birth in 2001, attracting rapidly growing attention of scientific institutes and …

Diagnostic accuracy of serum matrix metalloproteinase‐7 for biliary atresia

L Yang, Y Zhou, P Xu, R Mourya, H Lei, G Cao… - Hepatology, 2018 - journals.lww.com
Recent studies have indicated that a number of long noncoding RNAs (lncRNAs) are
dysregulated in hepatocellular carcinoma, while their aberrant expressions are associated …

MicroRNA profile in HBV-induced infection and hepatocellular carcinoma

G Wang, F Dong, Z Xu, S Sharma, X Hu, D Chen… - BMC cancer, 2017 - Springer
Background MicroRNAs (miRNAs) exhibit essential regulatory functions related to cell
growth, apoptosis, development and differentiation. Dysregulated expression of miRNAs is …

Hepatitis B virus X protein mediated epigenetic alterations in the pathogenesis of hepatocellular carcinoma

L Yang, T Zou, Y Chen, Y Zhao, X Wu, M Li, F Du… - Hepatology …, 2022 - Springer
Chronic hepatitis B virus (HBV) infection is a worldwide health problem. Hepatitis B virus X
protein (HBx), a pleiotropic regulatory protein encoded by HBV, is necessary for the …

PROTACs in gastrointestinal cancers

Y Chen, Q Yang, J Xu, L Tang, Y Zhang, F Du… - Molecular Therapy …, 2022 - cell.com
Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …

[HTML][HTML] Significance of hepatitis virus infection in the oncogenic initiation of hepatocellular carcinoma

CHC Sukowati, KE El-Khobar, SI Ie… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death
worldwide. Chronic infection of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) is a …

Multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors

RJ Paproski, A Heinmiller, K Wachowicz, RJ Zemp - Scientific reports, 2014 - nature.com
Photoacoustic imaging is an emerging hybrid imaging technology capable of breaking
through resolution limits of pure optical imaging technologies imposed by optical-scattering …

Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus

K Montrose, GW Krissansen - Biochemical and Biophysical Research …, 2014 - Elsevier
The X-protein of the hepatitis B virus (HBV) is essential for virus infection and contributes to
the development of HBV-induced hepatocellular carcinoma (HCC), a disease which causes …

Hepatitis B Virus–Upregulated LNC‐HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity

N Liu, Q Liu, X Yang, F Zhang, X Li, Y Ma, F Guan… - Hepatology, 2018 - journals.lww.com
Recent studies have indicated that a number of long noncoding RNAs (lncRNAs) are
dysregulated in hepatocellular carcinoma, while their aberrant expressions are associated …