Abstract Acute Respiratory Distress Syndrome (ARDS) is one of the most demanding
conditions in an Intensive Care Unit (ICU). Management of analgesia and sedation in ARDS …

COVID-19 pneumonia is associated with hypoxaemic respiratory failure, ranging from mild
to severe. Because of the worldwide shortage of ICU beds, a relatively high number of …

Background Since the publication of the 2018 Clinical Guidelines about sedation, analgesia,
delirium, mobilization, and sleep deprivation in critically ill patients, no evaluation and …

Background Despite the expanding literature that discusses insights into the clinical picture
and mechanisms by which the SARS-CoV-2 virus invades the nervous system, data on the …

Purpose The purpose of this study is to reflect upon the ramifications of two decades of Lean
Six Sigma implementations in Dutch healthcare institutions in the light of the current COVID …

The uncertainty of coronavirus disease 2019 (COVID-19) caused anticipatory purchasing of
medications around the world, driving demand to an unprecedented high. Meanwhile, drug …

Background The pharmaceutical field faces a significant challenge in validating drug target
interactions (DTIs) due to the time and cost involved, leading to only a fraction being …

Purpose In this retrospective study, we compared inhaled sedation with isoflurane to
intravenous propofol in invasively ventilated COVID-19 patients with ARDS (Acute …

Coronavirus Disease 2019 is predominantly a disorder of the respiratory system, but
neurological complications have been recognised since early in the pandemic. The major …

Background Patients with COVID-19 acute respiratory distress syndrome (ARDS) have been
shown to have high sedation requirements. Objective The purpose of this study was to …