In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …

In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …

It has become increasingly difficult to find an area of cell biology in which lipids do not have
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …

Metabolome reflects the interplay of genome and exposome at molecular level and thus can
provide deep insights into the pathogenesis of a complex disease like major depression. To …

“Sphingosin” was first described by JLW Thudichum in 1884 and structurally characterized
as 2S, 3R, 4E-2-aminooctadec-4-ene-1, 3-diol in 1947 by Herb Carter, who also proposed …

Several biological processes in prokaryotic and eukaryotic organisms require the presence
of glycolipids (biosurfactants), compounds with both hydrophilic and hydrophobic groups in …

Sphingolipids, a family of membrane lipids, are bioactive molecules that participate in
diverse functions controlling fundamental cellular processes such as cell division …

The role of vitamin K in the nervous system has been somewhat neglected compared with
other physiological systems despite the fact that this nutrient was identified some 40 y ago …

Acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, hydrolyzes
sphingomyelin to ceramide and phosphorylcholine. In mammals, the expression of a single …

Hereditary sensory and autonomic neuropathy type I (HSAN-I) is an axonal peripheral
neuropathy associated with progressive distal sensory loss and severe ulcerations …