Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …

During the past decade, proof of the principle that peptide receptors can be used
successfully for in vivo targeting of human cancers has been provided. The molecular basis …

The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are
known primarily for their ability to transport molecules across endothelial cells, but modern …

Among the membrane compartments of a cell, vesicles known as “caveolae” have long
defied functional characterization. However, since the identification of a family of proteins …

GnRH and its analogs are used extensively for the treatment of hormone-dependent
diseases and assisted reproductive techniques. They also have potential as novel …

Several groups have provided evidence that positron emission tomography (PET) and
single-photon emission computed tomography (SPECT) neuroreceptor imaging techniques …

Binding of hormones, growth factors and other cell modulators to cell-surface receptors
triggers a complex array of signal-transduction events. The activation of many receptors also …

The endocytic pathway tightly controls the activity of G protein–coupled receptors (GPCRs).
Ligand-induced endocytosis can drive receptors into divergent lysosomal and recycling …

Substance P is released in the spinal cord in response to painful stimuli, but its role in
nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome …

Sequestration of G protein-coupled receptors from the cell surface is a commonly observed
phenomenon following agonist-stimulation. This process is now believed to be important for …