The need for consistency in analytical method development reinforces the dependence of
pharmaceutical product development and manufacturing on robust analytical data. The …

Robustness has been defined as being the capacity of an analytical procedure to produce
unbiased results when small changes in the experimental conditions are made voluntarily …

Abstract An innovative Analytical Quality-by-Design (AQbD) methodology was followed to
develop a specific and robust UHPLC method for the simultaneous separation of 16 active …

The quality by design strategy was applied for the simultaneous chromatographic
quantification of a binary mixture of bromhexine HCl and its pharmacologically active …

Sulfonamides and trimethoprim combinations have been used extensively as antimicrobial
agents for prevention and treatment of human and animal infections. Although many …

In this review, quality by design (QbD) initiatives are described as applications for many
types of processes, such as in the pharmaceutical industry, biotechnology field, and for …

This work presented the integration of the Analytical Quality by Design concept in
developing a UPLC method for the quantification of saponins and phenolic acids in two …

Faced to the large number of potential factors in liquid chromatography, the analyst is often
led to determine through his experience the parameters to be studied. Experimental designs …

A new, sensitive, robust RP-HPLC method was developed using quality by design (QbD)
approach for the determination of perampanel in pharmaceutical tablets. Screening of five …

A liquid chromatographic method has been established for the separation of five presently
existing anti-diabetic drugs—metformin, pioglitazone, glibenclamide, glimepiride and …