Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system

E Dzyubenko, DM Hermann - Seminars in Immunopathology, 2023 - Springer
Neuronal plasticity is critical for the maintenance and modulation of brain activity. Emerging
evidence indicates that glial cells actively shape neuroplasticity, allowing for highly flexible …

[HTML][HTML] Brain cancer stem cells in adults and children: cell biology and therapeutic implications

TJ Abou-Antoun, JS Hale, JD Lathia, SM Dombrowski - Neurotherapeutics, 2017 - Elsevier
Brain tumors represent some of the most malignant cancers in both children and adults.
Current treatment options target the majority of tumor cells but do not adequately target self …

Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T

JO Nuninga, RCW Mandl, MP Boks, S Bakker… - Molecular …, 2020 - nature.com
Electroconvulsive therapy (ECT) is the most effective treatment for depression, yet its
working mechanism remains unclear. In the animal analog of ECT, neurogenesis in the …

First episode psychosis and schizophrenia are systemic neuro-immune disorders triggered by a biotic stimulus in individuals with reduced immune regulation and …

M Maes, K Plaimas, A Suratanee, C Noto… - Cells, 2021 - mdpi.com
There is evidence that schizophrenia is characterized by activation of the immune-
inflammatory response (IRS) and compensatory immune-regulatory systems (CIRS) and …

[HTML][HTML] Continuous theta-burst stimulation enhances and sustains neurogenesis following ischemic stroke

X Zong, J Gu, S Zhou, D Ding, Y Hu, L Tucker… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Previous work has indicated that continuous theta-burst stimulation (cTBS), a
modality of transcranial magnetic stimulation (TMS), may provide neuroprotection and …

[HTML][HTML] Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease

E Coninx, YC Chew, X Yang, W Guo… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Epigenetic clocks are based on age-associated changes in DNA methylation of CpG-sites,
which can accurately measure chronological age in different species. Recently, several …

Unraveling human brain development and evolution using organoid models

S Fernandes, D Klein, MC Marchetto - Frontiers in Cell and …, 2021 - frontiersin.org
Brain organoids are proving to be physiologically relevant models for studying human brain
development in terms of temporal transcriptional signature recapitulation, dynamic …

Integrative analysis of DNA methylation and gene expression identifies genes associated with biological aging in Alzheimer's disease

BH Kim, A Vasanthakumar, QS Li… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction The acceleration of biological aging is a risk factor for Alzheimer's disease (AD).
Here, we performed weighted gene co‐expression network analysis (WGCNA) to identify …

[HTML][HTML] Ameliorating effect of continuous alpha-glycosyl isoquercitrin treatment starting from late gestation in a rat autism model induced by postnatal injection of …

H Okano, K Takashima, Y Takahashi, R Ojiro… - Chemico-Biological …, 2022 - Elsevier
The present study investigated the role of neuroinflammation and brain oxidative stress
induced by neonatal treatment with lipopolysaccharides (LPS) on the development of autism …

[HTML][HTML] Molecular bases of Alzheimer's disease and neurodegeneration: the role of neuroglia

A Luca, C Calandra, M Luca - Aging and disease, 2018 - ncbi.nlm.nih.gov
Neuroglia is an umbrella term indicating different cellular types that play a pivotal role in the
brain, being involved in its development and functional homeostasis. Glial cells are …