Cucurbiturils: from synthesis to high-affinity binding and catalysis
In the wide area of supramolecular chemistry, cucurbit [n] urils (CBn) present themselves as
a young family of molecular containers, able to form stable complexes with various guests …
a young family of molecular containers, able to form stable complexes with various guests …
Applications of cucurbiturils in medicinal chemistry and chemical biology
The supramolecular chemistry of cucurbit [n] urils (CB n) has been rapidly developing to
encompass diverse medicinal applications, including drug formulation and delivery …
encompass diverse medicinal applications, including drug formulation and delivery …
Cucurbituril chemistry: a tale of supramolecular success
This review highlights the past six year advances in the blossoming field of cucurbit [n] uril
chemistry. Because of their exceptional recognition properties in aqueous medium, these …
chemistry. Because of their exceptional recognition properties in aqueous medium, these …
The strategic use of supramolecular pKa shifts to enhance the bioavailability of drugs
Macrocyclic hosts of the cyclodextrin, sulfonatocalixarene, and cucurbituril type can be
employed as discrete supramolecular drug delivery systems, thereby complementing …
employed as discrete supramolecular drug delivery systems, thereby complementing …
Cucurbit [7] uril: an emerging candidate for pharmaceutical excipients
KI Kuok, S Li, IW Wyman… - Annals of the New York …, 2017 - Wiley Online Library
Cucurbit [7] uril (CB [7]), belonging to the cucurbit [n] uril family (CB [n], n= 5–8, 10, or 13–
15), may form host–guest complexes with a variety of small molecules of biomedical interest …
15), may form host–guest complexes with a variety of small molecules of biomedical interest …
Cucurbit[n]urils as excipients in pharmaceutical dosage forms
NJ Wheate, C Limantoro - Supramolecular Chemistry, 2016 - Taylor & Francis
Native, unfunctionalised cucurbit [n] urils (n= 6, 7, or 8) have shown enormous potential as
excipients in medical formulations for improving drug delivery. Specific benefits include …
excipients in medical formulations for improving drug delivery. Specific benefits include …
A systematic evaluation of the biocompatibility of cucurbit [7] uril in mice
As one of the most water-soluble members in the macrocyclic cucurbit [n] uril (CB [n]) family,
CB [7] has attracted increasing attention in pharmaceutical and biomedical fields. Despite …
CB [7] has attracted increasing attention in pharmaceutical and biomedical fields. Despite …
Absolute and relative binding affinity of cucurbit [7] uril towards a series of cationic guests
We determined the relative binding constants (K rel) for guests 1–19 towards cucurbit [7] uril
by 1H NMR competition experiments in 100 mM Na3PO4-buffered D2O. In these …
by 1H NMR competition experiments in 100 mM Na3PO4-buffered D2O. In these …
A Cucurbit[8]uril 2:2 Complex with a Negative pKa Shift
A viologen derivative carrying a benzimidazole group (V‐P‐I 2+; viologen–phenylene–
imidazole V‐P‐I) can be dimerized in water using cucurbit [8] uril (CB [8]) in the form of a 2: 2 …
imidazole V‐P‐I) can be dimerized in water using cucurbit [8] uril (CB [8]) in the form of a 2: 2 …
Comparison of Complexation-Induced pKa Shifts in the Ground and Excited States of Dyes as Well as Different Macrocyclic Hosts and Their Manifestation in Host …
1-Aminopyrene and 1-naphthylamine-5-sulfonic acid were converted to the putrescine (1, 4-
diaminobutane)-substituted derivatives (dyes 1 and 2). The diaminobutyl anchor serves as a …
diaminobutane)-substituted derivatives (dyes 1 and 2). The diaminobutyl anchor serves as a …