Rapid rise of antimicrobial resistance against conventional antimicrobials, resurgence of
multidrug resistant microbes and the slowdown in the development of new classes of …

Peptides are important biological molecular entities in biomedical research. They can be
prepared in a large variety of shapes, with a host of chemical functions, and tailored for …

The use of non-standard toxicity models is a hurdle in the early development of antimicrobial
peptides towards clinical applications. Herein we report an extensive in vitro and in vivo …

The proliferation and global expansion of multidrug-resistant (MDR) bacteria have
deepened the need to develop novel antimicrobials. Antimicrobial peptides (AMPs) are …

Membrane disruptive α-helical antimicrobial peptides (AMPs) offer an opportunity to address
multidrug resistance; however, most AMPs are toxic and unstable in serum. These …

Overuse and misuse of antibacterial drugs has resulted in bacteria resistance and in an
increase in mortality rates due to bacterial infections. Therefore, there is an imperative …

Antimicrobial resistance threatens the achievements of science and medicine, as it
deactivates conventional antimicrobial therapeutics. Scientists respond to the threat by …

The emergence of multidrug resistant bacteria has a direct impact on global public health
because of the reduced potency of existing antibiotics against pathogens. Hence, there is a …

Conspectus The alarming rate at which micro-organisms are developing resistance to
conventional antibiotics represents one of the global challenges of our time. There is …

A series of new conjugates comprised from a small synthetic antimicrobial peptide (AMP)
and a siderophore‐type vector component was designed and tested for activity on P …