[HTML][HTML] Antibacterial Activity of Green Synthesized Silver Nanoparticles Using Lawsonia inermis Against Common Pathogens from Urinary Tract Infection

A Said, M Abu-Elghait, HM Atta, SS Salem - Applied Biochemistry and …, 2024 - Springer
New and creative methodologies for the fabrication of silver nanoparticles (Ag-NPs), which
are exploited in a wide range of consumer items, are of significant interest. Hence, this …

[HTML][HTML] Innovative delivery and release systems for antioxidants and other active substances in the treatment of cancer

Z Sezgin-Bayindir, S Losada-Barreiro… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major diseases leading to death worldwide, and the fight against the
disease is still challenging. Cancer diseases are usually associated with increased oxidative …

[HTML][HTML] The involvement of photobiology in contemporary dentistry—A narrative review

I Luchian, DG Budală, ER Baciu, RG Ursu… - International Journal of …, 2023 - mdpi.com
Light is an emerging treatment approach that is being used to treat many diseases and
conditions such as pain, inflammation, and wound healing. The light used in dental therapy …

[HTML][HTML] Multi-step in silico discovery of natural drugs against COVID-19 targeting main protease

EB Elkaeed, FS Youssef, IH Eissa, H Elkady… - International Journal of …, 2022 - mdpi.com
In continuation of our antecedent work against COVID-19, three natural compounds, namely,
Luteoside C (130), Kahalalide E (184), and Streptovaricin B (278) were determined as the …

[HTML][HTML] A multistage in silico study of natural potential inhibitors targeting SARS-CoV-2 main protease

EB Elkaeed, IH Eissa, H Elkady, A Abdelalim… - International Journal of …, 2022 - mdpi.com
Among a group of 310 natural antiviral natural metabolites, our team identified three
compounds as the most potent natural inhibitors against the SARS-CoV-2 main protease …

[HTML][HTML] In Silico Exploration of Potential Natural Inhibitors against SARS-Cov-2 nsp10

IH Eissa, MM Khalifa, EB Elkaeed, EE Hafez… - Molecules, 2021 - mdpi.com
In continuation of our previous effort, different in silico selection methods were applied to
310 naturally isolated metabolites that exhibited antiviral potentialities before. The applied …

[HTML][HTML] New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies

EB Elkaeed, RG Yousef, H Elkady, AA Alsfouk… - Molecules, 2022 - mdpi.com
Based on the pharmacophoric features of EGFR inhibitors, a new semisynthetic
theobromine-derived compound was designed to interact with the catalytic pocket of EGFR …

Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and …

IH Eissa, RG Yousef, H Elkady, EB Elkaeed… - … Biology and Chemistry, 2023 - Elsevier
A group of theobromine derivatives was designed based on the key pharmacophoric
characteristics of VEGFR-2 inhibitors. HepG2 and MCF-7 cancer cell lines were used to test …

[HTML][HTML] In Silico Screening of Semi-Synthesized Compounds as Potential Inhibitors for SARS-CoV-2 Papain-like Protease: Pharmacophoric Features, Molecular …

MS Alesawy, EB Elkaeed, AA Alsfouk, AM Metwaly… - Molecules, 2021 - mdpi.com
Papain-like protease is an essential enzyme in the proteolytic processing required for the
replication of SARS-CoV-2. Accordingly, such an enzyme is an important target for the …

Anti-breast cancer potential of a new xanthine derivative: in silico, antiproliferative, selectivity, VEGFR-2 inhibition, apoptosis induction and migration inhibition studies

IH Eissa, RG Yousef, H Elkady, EB Elkaeed… - … -Research and Practice, 2023 - Elsevier
Background The overexpression of VEGFR-2 receptors in breast cancer provides a valuable
approach to anticancer strategies. Targeting VEGFR-2, a new semisynthetic compound (T-1 …